The Center of Excellence for Protein Studies is located at NRL’s laboratory in ICAD, Abu Dhabi. The laboratory provides comprehensive specialized testing for the diagnosis of plasma cell disorders (dyscrasias), and was set up with the support of LabCorp’s specialty laboratory network.

Plasma cell disorders (dyscrasias) are diverse group of diseases characterized by clonal protein production. Symptoms occur mainly due to clonal expansion, but also due to effects of the abnormal proteins. There are several types of plasma cell neoplasms, including monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma.

Unlike normal plasma cells, myeloma cells release only one type of antibody. This single antibody (monoclonal antibody) is known as the M-protein or paraprotein. In some cases the antibody produced is incomplete, consisting of only light chains or only heavy chains.

The testing includes:

- Complete Blood Count - identifies count of white cells, red cells and platelets and other indicators of blood composition.

- Protein Electrophoresis - detects the presence of M-protein and measures its amount in serum and urine.

- Protein Immunofixation Electrophoresis – performed on serum and urine samples to identify the specific type of the protein that is produced by the malignant plasma cells.

- Serum Free Light Chain Assay - provides complementary information, by detecting the excessive free light chains that may be produced by malignant cells and detecting the changes in the ratio of kappa and lambda production. Useful monitoring tool in patients with oligosecretory multiple myeloma. Assays for free kappa and free lambda light chains are now recommended as an integral component of the screening algorithm for monoclonal gammopathy, for serial monitoring in patients without measurable disease by other methods, as a valuable prognostic tool, and as a component of the stringent complete response criterion in multiple myeloma.           

- Quantitative Immunoglobulins - tests that measure the amount of the different types of immunoglobulins or antibodies in the blood.  

In addition to the in-house test, we offer the following testing through our partner LabCorp:

- Cytogenetic Testing - identifies chromosomal abnormalities which is important to guide treatment choices. 

- Multiple Myeloma Enriched Microarray Tests

•    Multiple Myeloma Enriched Microarray and Multiple Myeloma FISH
•    Multiple Myeloma Enrichment SNP Microarray−Oncology (Reveal®)

In-house Test Menu

Order Code

Order Code Name

CPT Code

Specimen type

Volume

Specimen container

Specimen

stability

Storage

TAT days

Testing Frequency

001685

Immunofixation (IFE), Serum

82784 (x3), 86334

Serum

1 mL

Red/Yellow Top

7 days at 2‑8 °C,

Refrigerate

2 days

Sun-Tue-Thu

123034

Immunofixation (IFE), Urine

86335

Urine

5 mL

Urine Cup

7 days at 2‑8 °C,

Refrigerate

2 days

Sun-Tue-Thu

001495

Protein Electrophoresis and Immunofixation, Serum

82784 (x3), 84155, 84165, 86334

Serum

1 mL

Red/Yellow Top

7 days at 2‑8 °C,

Refrigerate

2 days

Sun-Tue-Thu

122390

Protein Electrophoresis and Immunofixation, Random Urine

84156, 84166, 86335

Urine

5 mL

Urine Cup

7 days at 2‑8 °C,

Refrigerate

2 days

Sun-Tue-Thu

003467

Protein Electrophoresis and Immunofixation, 24-Hour Urine

84156, 84166, 86335

Urine

5 mL

Urine Cup

7 days at 2‑8 °C,

Refrigerate

2 days

Sun-Tue-Thu

001784

Immunoglobulin A

82784

Serum

0.5 ml

Red top tube or gel barrier tube

8 months at 2-8 °C

Refrigerate

1 day

 

Daily

002170

Immunoglobulin E

82785

Serum

0.5 ml

Red top tube or gel barrier tube

7 days at 2-8 °C

Refrigerate

1 day

Daily

001776

Immunoglobulin G

82784

Serum

0.5 ml

Red top tube or gel barrier tube

8 months at 2-8 °C

Refrigerate

1 day

Daily

001792

Immunoglobulin M

82784

Serum

0.5 ml

Red top tube or gel barrier tube

4 months at 2-8 °C

Refrigerate

1 day

Daily

002295

Immunoglobulins A/E/G/M, Serum

82784 (x3),82785

Serum

1.5 ml

Red top tube or gel barrier tube

See individual stability times

Refrigerate

1 day

Daily

001768

Immunoglobulins A/G/M, Qn, Ser

82784 (x3)

Serum

1.5 ml

Red top tube or gel barrier tube

See individual stability times

Refrigerate

1 day

Daily

10095

Free Light Chains + Ratio

Includes

  1. Free Kappa Lt Chains
  2. Free Lambda Lt Chains
  3. Kappa/Lambda Ratio

83883X2

Serum

1mL

Red-top tube or gel-barrier tube

21 days once serum has been separated from cells within 30 minutes of collection

2-8°C

5 days

Sunday & Tuesday

 

Collection requirements/information for order code 10095:

Recommended:  Patient should be fasting for eight hours to avoid lipemic sample interference.

Values obtained with different assay methods should not be used interchangeably in serial testing. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy.