Pyridoxal 5'-phosphate (CSF)

18 days

Cause for Rejection:
Received thawed

Accredited Laboratory Partner

CSF pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is useful for evaluating disorders associated with reduced central nervous system PLP availability. PLP is an essential cofactor for numerous enzymes involved in neurotransmitter and amino acid metabolism. CSF PLP measurement may aid in the diagnosis of inherited disorders affecting vitamin B6 metabolism, including pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency, ALDH7A1 (antiquitin) deficiency and hyperprolinemia type II, and Hyperphosphatasia with Mental Retardation Syndrome (HPMRS, Mabry Syndrome).

Cerebrospinal fluid (CSF) from a lumbar puncture (LP)

0.5 mL

LabCorp 5-Tube CSF Collection Kit (recommended)

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Sample Collection and Handling Instructions Single-Tube Collection (if no additional testing is ordered): Collect the entire sample into a single sterile tube from a standard LP. IMPORTANT: If additional tests are ordered concurrently, use the LabCorp 5-Tube CSF Collection Kit (PS# 125218). Each kit contains five microcentrifuge tubes. CSF Collection Protocol Collect CSF starting from the first drop directly into the first tube. Do not aliquot from a pooled sample. Fill tubes in numerical order, to the volume listed below: - Tube 1: 0.5 mL - Tube 2: 1.0 mL - Tube 3: 1.0 mL (contains antioxidants to preserve sample integrity) - Tube 4: 1.0 mL - Tube 5: 1.0 mL Handling after collection: - If no blood contamination: --> Place tubes on dry ice immediately at bedside. - If blood contamination is present: --> Centrifuge immediately (before freezing) --> Transfer clear CSF to new, correspondingly labeled tube --> Then place the tube on dry ice immediately. Label tubes with patient name and ID number, leaving the tube number viewable. Complete LabCorp Neurochemistry request form. Include test required, sample date and date of birth.