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NRAS Gene Mutation Analysis, Extended

Order Code
570168
CPT
81311; 88381
Test Details
TAT

11 days

Methodology

SNaPshot Multiplex PCR (primer extension-based method)

Remarks

Provide a copy of the pathology report; the NRAS test will be delayed if the pathology report is not received

Performing Location

Accredited Laboratory Partner

Testing Frequency

Not appplicable

Test Overview

NRAS is a guanosine triphosphate (GTP)-binding protein involved in downstream receptor signaling, which is critical for cell proliferation, survival and differentiation. Mutations in the NRAS oncogene are frequently found in human cancers. They are common in melanomas, colorectal cancer and thyroid cancer. This assay detects NRAS mutations in exons 2, 3 and 4, allowing the determination of drug response.

Specimen Type

Formalin-fixed, paraffin-embedded (FFPE) tissue or slides

Volume

Formalin-fixed, paraffin-embedded tissue block or four unstained slides and one matching H&E-stained slide at 5 μM

Specimen Container

Formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slides

Specimen Stability
Temperature Period
Room temperature To be determined
Order Code
570168
CPT
81311; 88381
Test Details
TAT

11 days

Methodology

SNaPshot Multiplex PCR (primer extension-based method)

Remarks

Provide a copy of the pathology report; the NRAS test will be delayed if the pathology report is not received

Performing Location

Accredited Laboratory Partner

Testing Frequency

Not appplicable

Test Overview

NRAS is a guanosine triphosphate (GTP)-binding protein involved in downstream receptor signaling, which is critical for cell proliferation, survival and differentiation. Mutations in the NRAS oncogene are frequently found in human cancers. They are common in melanomas, colorectal cancer and thyroid cancer. This assay detects NRAS mutations in exons 2, 3 and 4, allowing the determination of drug response.

Specimen Type

Formalin-fixed, paraffin-embedded (FFPE) tissue or slides

Volume

Formalin-fixed, paraffin-embedded tissue block or four unstained slides and one matching H&E-stained slide at 5 μM

Specimen Container

Formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slides

Specimen Stability
Temperature Period
Room temperature To be determined