IgVH Mutation Analysis

Immunoglobulin Heavy Chain Variable Region Mutation Analysis

12 days

The immunoglobulin heavy-chain gene variable region (IgVH) somatic hypermutation analysis is performed using extracted patient RNA as starting material. Subsequent amplification of the IgH gene is performed by polymerase chain reaction (PCR). The PCR products are isolated and sequenced. The nucleotide sequence is compared to a consensus germLine sequence data base for that VH gene family.

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Evaluates somatic hypermutation status of the immunoglobulin heavy chain variable region gene (IgVH). Prognostic marker in chronic lymphocytic leukemia (CLL), where mutated status is associated with better outcomes.

Peripheral Blood or Bone Marrow

1 mL

Lavender-top (EDTA) tube, green-top (heparin) tube or yellow-top (ACD) tube

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.