High-Grade B-Cell Lymphoma, FISH

10 days

Fluorescence in situ hybridization (FISH)

Test Includes This test includes fluorescence in situ hybridization (FISH) for aggressive B‐cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC. Special Instructions Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.

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Pathology or molecular panel used to characterize aggressive B-cell lymphomas. Guides diagnosis and treatment planning.

Whole blood, bone marrow, CSF, lymph node, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei, bone marrow touch preparation slides, paraffin slides OR block are acceptable for testing.

5mL whole blood (pediatric), 3mL bone marrow, fixed-cellpellet from a cytogenetic analysis, 6 slides with metaphaseand/or interphase nuclei OR 6 touch preparation slides OR six slides 4- or 5-micron thick with tumor

Green-top (sodium heparin) tube; pediatric Vacutainer(R) is optimal. OR lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube,

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.