14 days
The Nijmegen modification of the classic Bethesda inhibitor titration assay is used in a chromogenic factor VIII activity setting. Patient sample is heat-inactivated and clarified, then a serial dilution series is prepared in buffered normal plasma containing bovine serum albumin. A chromogenic factor activity is measured to determine residual activity and the inhibitor concentration is determined using an equation that relates the log % residualactivity to inhibitor titer.
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Specialized chromogenic inhibitor assay compatible with Emicizumab therapy. Used in Hemophilia A management.
Plasma, Frozen
2 mL
Blue top (sodium citrate) tube
The patient should not be anticoagulated Do not draw from an arm with a heparin lock or heparinized catheter
Citrated Plasma samples should be collected by double centrifugation
| Temperature | Period |
|---|---|
| Frozen | 12 months |