DME Genotyping
14 days
DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) and deletion within the CYP2C9 gene and to assign variant CYP2C9 *2, *3, *5, *6, *8, *11 and *13 alleles. *1 denoted detection of the reference (wild-type) sequence at the assessed alleles. No other variants in tis gene are detected by this assay.
Cause for Rejection: Haemolysis, quantity not sufficient for analysis, improper container, single buccal swab, wet buccal swab, buccal swabs without outer collection envelope, severly damaged buccal swab envelope, buccal swab envelope received open, frozen glass tube.
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Determines CYP2C9 genotype. Important for dosing warfarin and other drugs.
Whole Blood or LabCorp buccal swab kit (buccal swab collection kit contains 4 swabs and instructions for use of a buccal swab)
2 mL whole blood or one buccal swab kit (4 swabs)
Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit
No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.
This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.
| Temperature | Period |
|---|---|
| Room temperature | Whole Blood: 28 days Swabs: 2 Months |
| Refrigerated | Whole Blood: 28 days Swabs: Unstable |
| Frozen | Whole Blood: 2 years Swabs: Unstable |