18 days
High-pressure liquid chromatography (HPLC)
Storage Instructions
Freeze as soon as possible after collection.
Causes for Rejection
Bloody CSF; received thawed
Accredited Laboratory Partner
Contact Technical Support
CSF 5-Methyltetrahydrofolate (NC01) is useful for determining a deficiency of folate in the central nervous system. CSF 5-Methyltetrahydrofolate (NC01) may also be used for assessment of Variants of Uncertain Significance (VUS) identified during genetic testing (e.g. Next Generation Sequencing or Capillary Sequencing Testing). 5-Methyltetrahydrofolate (5-MTFH) is the predominant form of folate in cerebrospinal fluid (CSF). Low CSF 5-MTHF levels are associated with inborn errors of metabolism affecting folate metabolism, dietary deficiency of folate, cerebral folate syndromes and Kearns-Sayre syndrome. Symptoms may include, anemia, developmental delay, seizures, depression and dementia.
Cerebrospinal fluid (CSF)
1.0 mL
Sterile screw capped vial
No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.
Collect entire sample into a single sterile tube.
| Temperature | Period |
|---|---|
| Frozen | -20°C = 72 hours; -80°C = Indefinite (stability provided by manufacturer or literature reference) |
18 days
High-pressure liquid chromatography (HPLC)
Storage Instructions
Freeze as soon as possible after collection.
Causes for Rejection
Bloody CSF; received thawed
Accredited Laboratory Partner
Contact Technical Support
CSF 5-Methyltetrahydrofolate (NC01) is useful for determining a deficiency of folate in the central nervous system. CSF 5-Methyltetrahydrofolate (NC01) may also be used for assessment of Variants of Uncertain Significance (VUS) identified during genetic testing (e.g. Next Generation Sequencing or Capillary Sequencing Testing). 5-Methyltetrahydrofolate (5-MTFH) is the predominant form of folate in cerebrospinal fluid (CSF). Low CSF 5-MTHF levels are associated with inborn errors of metabolism affecting folate metabolism, dietary deficiency of folate, cerebral folate syndromes and Kearns-Sayre syndrome. Symptoms may include, anemia, developmental delay, seizures, depression and dementia.
Cerebrospinal fluid (CSF)
1.0 mL
Sterile screw capped vial
No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.
Collect entire sample into a single sterile tube.
| Temperature | Period |
|---|---|
| Frozen | -20°C = 72 hours; -80°C = Indefinite (stability provided by manufacturer or literature reference) |