Immunoglobulin Heavy Chain Variable Region Mutation Analysis
12 days
The immunoglobulin heavy-chain gene variable region (IgVH) somatic hypermutation analysis is performed using extracted patient RNA as starting material. Subsequent amplification of the IgH gene is performed by polymerase chain reaction (PCR). The PCR products are isolated and sequenced. The nucleotide sequence is compared to a consensus germLine sequence data base for that VH gene family.
Accredited Laboratory Partner
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Evaluates somatic hypermutation status of the immunoglobulin heavy chain variable region gene (IgVH). Prognostic marker in chronic lymphocytic leukemia (CLL), where mutated status is associated with better outcomes.
Peripheral Blood or Bone Marrow
1 mL
Lavender-top (EDTA) tube, green-top (heparin) tube or yellow-top (ACD) tube
No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.
This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.
| Temperature | Period |
|---|---|
| Room temperature | 5 days |
Immunoglobulin Heavy Chain Variable Region Mutation Analysis
12 days
The immunoglobulin heavy-chain gene variable region (IgVH) somatic hypermutation analysis is performed using extracted patient RNA as starting material. Subsequent amplification of the IgH gene is performed by polymerase chain reaction (PCR). The PCR products are isolated and sequenced. The nucleotide sequence is compared to a consensus germLine sequence data base for that VH gene family.
Accredited Laboratory Partner
Contact Technical Support
Evaluates somatic hypermutation status of the immunoglobulin heavy chain variable region gene (IgVH). Prognostic marker in chronic lymphocytic leukemia (CLL), where mutated status is associated with better outcomes.
Peripheral Blood or Bone Marrow
1 mL
Lavender-top (EDTA) tube, green-top (heparin) tube or yellow-top (ACD) tube
No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.
This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.
| Temperature | Period |
|---|---|
| Room temperature | 5 days |