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High-Grade B-Cell Lymphoma, FISH

Order Code
510344
CPT
88271x6, 88275x3
Test Details
TAT

10 days

Methodology

Fluorescence in situ hybridization (FISH)

Remarks

Test Includes This test includes fluorescence in situ hybridization (FISH) for aggressive B‐cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC. Special Instructions Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Pathology or molecular panel used to characterize aggressive B-cell lymphomas. Guides diagnosis and treatment planning.

Specimen Type

Whole blood, bone marrow, CSF, lymph node, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei, bone marrow touch preparation slides, paraffin slides OR block are acceptable for testing.

Volume

5mL whole blood (pediatric), 3mL bone marrow, fixed-cellpellet from a cytogenetic analysis, 6 slides with metaphaseand/or interphase nuclei OR 6 touch preparation slides OR six slides 4- or 5-micron thick with tumor

Specimen Container

Green-top (sodium heparin) tube; pediatric Vacutainer(R) is optimal. OR lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube,

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Specimen Stability
Temperature Period
Room temperature To be determined
Order Code
510344
CPT
88271x6, 88275x3
Test Details
TAT

10 days

Methodology

Fluorescence in situ hybridization (FISH)

Remarks

Test Includes This test includes fluorescence in situ hybridization (FISH) for aggressive B‐cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC. Special Instructions Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Pathology or molecular panel used to characterize aggressive B-cell lymphomas. Guides diagnosis and treatment planning.

Specimen Type

Whole blood, bone marrow, CSF, lymph node, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei, bone marrow touch preparation slides, paraffin slides OR block are acceptable for testing.

Volume

5mL whole blood (pediatric), 3mL bone marrow, fixed-cellpellet from a cytogenetic analysis, 6 slides with metaphaseand/or interphase nuclei OR 6 touch preparation slides OR six slides 4- or 5-micron thick with tumor

Specimen Container

Green-top (sodium heparin) tube; pediatric Vacutainer(R) is optimal. OR lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube,

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Specimen Stability
Temperature Period
Room temperature To be determined