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Factor XI Activity With Inhibitor Reflex

Order Code
086302
CPT
To be determined. Updates will be made when available.
Test Details
Synonyms

Factor XI Inactivator; Factor XI Bethesda Titer

TAT

11 days

Methodology

See individual activity test information for method information.

Remarks

Test Includes: Factor IX activity, factor IX Bethesda titer (Bethesda titer is not indicated and is canceled if the factor activity is >40%.)

Patient Preparation:
Ideally, the patient should not be on anticoagulant therapy. Avoid warfarin (Coumadin®) therapy for two weeks prior to the test and heparin, direct Xa and thrombin inhibitor therapies for about three days prior to testing. Do not draw from an arm with a heparin lock or heparinized catheter.

Causes for Rejection:
Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

This profile measures factor X activity and reflexes to a measurement of factor X inhibitor level (Bethesda titer) when the activity level is diminished to 40% or less.

Specimen Type

Plasma

Volume

2 mL

Specimen Container

Blue top (sodium citrate) tube

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples unless the sample is collected using a winged (butterfly) collection system. With a winged blood collection set, a discard tube should be drawn first to account for the dead space of the tubing and prevent under-filling of the evacuated tube. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternative anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes.

Specimen Stability
Temperature Period
Frozen 28 days
Freeze/thaw cycles Stable x3
Order Code
086302
CPT
To be determined. Updates will be made when available.
Test Details
Synonyms

Factor XI Inactivator; Factor XI Bethesda Titer

TAT

11 days

Methodology

See individual activity test information for method information.

Remarks

Test Includes: Factor IX activity, factor IX Bethesda titer (Bethesda titer is not indicated and is canceled if the factor activity is >40%.)

Patient Preparation:
Ideally, the patient should not be on anticoagulant therapy. Avoid warfarin (Coumadin®) therapy for two weeks prior to the test and heparin, direct Xa and thrombin inhibitor therapies for about three days prior to testing. Do not draw from an arm with a heparin lock or heparinized catheter.

Causes for Rejection:
Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

This profile measures factor X activity and reflexes to a measurement of factor X inhibitor level (Bethesda titer) when the activity level is diminished to 40% or less.

Specimen Type

Plasma

Volume

2 mL

Specimen Container

Blue top (sodium citrate) tube

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples unless the sample is collected using a winged (butterfly) collection system. With a winged blood collection set, a discard tube should be drawn first to account for the dead space of the tubing and prevent under-filling of the evacuated tube. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternative anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes.

Specimen Stability
Temperature Period
Frozen 28 days
Freeze/thaw cycles Stable x3