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Cytochrome P450 3A4/3A5 Genotyping

Order Code
512260
CPT
81230, 81231
Test Details
Synonyms

CYP3A4, CYP3A5

TAT

14 days

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) and insertions within the CYP3A4/3A5 genes and to assign variant CYP3A4 *22 and CYP3A5 *3, *6, and *7 alleles. *1 denotes detection of the reference (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Analyzes CYP3A4 and 3A5 genes. Affects metabolism of many medications.

Specimen Type

Whole Blood or LabCorp buccal swab kit (buccal swab collection kit contains 4 swabs and instructions for use of a buccal swab)

Volume

2 mL whole blood or one buccal swab kit (4 swabs)

Specimen Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit.

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.

Specimen Stability
Temperature Period
Room temperature Whole Blood: 28 days Swabs: 2 Months
Refrigerated Whole Blood: 28 days Swabs: Unstable
Frozen Whole Blood: 2 years Swabs: Unstable
Order Code
512260
CPT
81230, 81231
Test Details
Synonyms

CYP3A4, CYP3A5

TAT

14 days

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) and insertions within the CYP3A4/3A5 genes and to assign variant CYP3A4 *22 and CYP3A5 *3, *6, and *7 alleles. *1 denotes detection of the reference (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Analyzes CYP3A4 and 3A5 genes. Affects metabolism of many medications.

Specimen Type

Whole Blood or LabCorp buccal swab kit (buccal swab collection kit contains 4 swabs and instructions for use of a buccal swab)

Volume

2 mL whole blood or one buccal swab kit (4 swabs)

Specimen Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit.

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.

Specimen Stability
Temperature Period
Room temperature Whole Blood: 28 days Swabs: 2 Months
Refrigerated Whole Blood: 28 days Swabs: Unstable
Frozen Whole Blood: 2 years Swabs: Unstable