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Cytochrome P450 2C19 Genotyping

Order Code
512212
CPT
81225
Test Details
Synonyms

DME Genotyping

TAT

14 days

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) within the CYP2C19 gene and to assign variant CYP2C19 *2, *3, *4, *5, *6, *7, *8, *9, *10, *17 and *35 alleles. *1 denotes detection of the reference (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Remarks

Cause for Rejection: Haemolysis, quantity not sufficient for analysis, improper container, single buccal swab, wet buccal swab, buccal swabs without outer collection envelope, severly damaged buccal swab envelope, buccal swab envelope received open, frozen glass tube.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Genetic test for CYP2C19 variants. Guides drug metabolism predictions.

Specimen Type

Whole Blood or LabCorp buccal swab kit (buccal swab collection kit contains 4 swabs and instructions for use of a buccal swab)

Volume

2 mL whole blood or one buccal swab kit (4 swabs)

Specimen Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.

Specimen Stability
Temperature Period
Room temperature Whole Blood: 28 days Swabs: 2 Months
Refrigerated Whole Blood: 28 days Swabs: Unstable
Frozen Whole Blood: 2 years Swabs: Unstable
Order Code
512212
CPT
81225
Test Details
Synonyms

DME Genotyping

TAT

14 days

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) within the CYP2C19 gene and to assign variant CYP2C19 *2, *3, *4, *5, *6, *7, *8, *9, *10, *17 and *35 alleles. *1 denotes detection of the reference (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Remarks

Cause for Rejection: Haemolysis, quantity not sufficient for analysis, improper container, single buccal swab, wet buccal swab, buccal swabs without outer collection envelope, severly damaged buccal swab envelope, buccal swab envelope received open, frozen glass tube.

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Genetic test for CYP2C19 variants. Guides drug metabolism predictions.

Specimen Type

Whole Blood or LabCorp buccal swab kit (buccal swab collection kit contains 4 swabs and instructions for use of a buccal swab)

Volume

2 mL whole blood or one buccal swab kit (4 swabs)

Specimen Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

This test does not require any special collection or pre-analytical handling. Follow routine specimen collection protocols.

Specimen Stability
Temperature Period
Room temperature Whole Blood: 28 days Swabs: 2 Months
Refrigerated Whole Blood: 28 days Swabs: Unstable
Frozen Whole Blood: 2 years Swabs: Unstable