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B-Cell Gene Rearrangements Profile, IGH and IGK

Order Code
481222
CPT
81261, 81264
Test Details
Synonyms

IGH Gene Rearrangement Assay, IGH Clonality Assay, IGK Gene Rearrangement Assay, IGK Clonality Assay

TAT

11 days

Methodology

Polymerase chain reaction (PCR)

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Detects immunoglobulin heavy (IGH) and kappa (IGK) chain gene rearrangements. Helps diagnose lymphoid malignancies.

Specimen Type

Whole Blood, Bone Marrow, formalin-fixed paraffin-embedded (FFPE) tissue block or Slides fresh or Frozen tissue

Volume

3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen

Specimen Container

Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, tan-top (K2-EDTA) tube and pink-top (K2-EDTA) tube, FFPE tissue block or slides, tissue in RPMI or frozen

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (e.g., punch biopsies, fine-needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate specimens for each test requested.

Specimen Stability
Temperature Period
Refrigerated blood, bone marrow or tissue in RPMI
Frozen Tissue
Order Code
481222
CPT
81261, 81264
Test Details
Synonyms

IGH Gene Rearrangement Assay, IGH Clonality Assay, IGK Gene Rearrangement Assay, IGK Clonality Assay

TAT

11 days

Methodology

Polymerase chain reaction (PCR)

Performing Location

Accredited Laboratory Partner

Testing Frequency

Contact Technical Support

Test Overview

Detects immunoglobulin heavy (IGH) and kappa (IGK) chain gene rearrangements. Helps diagnose lymphoid malignancies.

Specimen Type

Whole Blood, Bone Marrow, formalin-fixed paraffin-embedded (FFPE) tissue block or Slides fresh or Frozen tissue

Volume

3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen

Specimen Container

Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, tan-top (K2-EDTA) tube and pink-top (K2-EDTA) tube, FFPE tissue block or slides, tissue in RPMI or frozen

Patient Preparation

No special preparation is required for this test. You may eat, drink, and take your medications as normal, unless instructed otherwise by your healthcare provider.

Collection

Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (e.g., punch biopsies, fine-needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate specimens for each test requested.

Specimen Stability
Temperature Period
Refrigerated blood, bone marrow or tissue in RPMI
Frozen Tissue